斯特威在路易斯救他脱离厕所溺水后对她产生了过分的依恋。他开始追求她的关注和爱，这让路易斯感到烦恼，而皮特则感到嫉妒。斯特威对路易斯的痴迷引发了这一集中一些喜剧和感人的瞬间。

Peter's mom gets a divorce. Peter feels abandoned until he sees a father figure in his mom's new boyfriend, Tom Tucker. Meanwhile, Brian gets his own NPR style show on the radio.

在Peter用Meg的钱买了一辆坦克后，她在镇上的新超级商店找到了一份工作。然而，这家超级商店使镇上所有的商店都破产了，吸走了城市的电力供应。Brian和Stewie联手拯救镇子免受这家企业巨头的影响。

当Peter受伤无法工作时，他的老板告诉他需要加快工作进度。所以Lois去啤酒厂帮助他。与此同时，Stewie发现Brian正在和一个非常漂亮但不太聪明的女人约会。他试图让Brian和她分手，但Brian做不到。

Lois discovers that Chris has some bad information about sex and she volunteers to teach a sex-ed class at the high school. Some parents become upset with her brutal honesty, and they have her replaced. A conservative christian comes to Quahog and gets rid of the condoms at James Woods High. As a result the kids find an interesting loophole. Meanwhile Stewie, terrified of the Tooth Fairy, decides to set traps to destroy him.

Stewie ties the knot with his old flame Olivia, but their relationship quickly turns, and becomes normal dull marriage. It all escalates when they go on a double date with Brian and Jillian. Meanwhile, Lois introduces Peter to chick flicks, so he decides to make his own movie with a plot based on every chick movie ever.

Meg can't find a date to her junior prom, and even though he is dating Jillian, Brian ends up going with Meg. At the prom, Brian gets drunk to make the night pass, but ends up making out with Meg. Meg begins to think of Brian as her boyfriend and becomes obsessed with spending every moment with him. Meanwhile, Peter, Cleveland and Quagmire join the police force to help Brian.

Brian sells Rupert at a garage sale. Stewie, who is upset with Brian, takes him cross country to Colorado to find his beloved teddy, and ends up having a ski-off to win back Rupert. Meanwhile, Peter loses his license, so Meg has to drive him around.

在Peter的父亲Francis去世后，Thelma告诉他，他的亲生父亲实际上住在爱尔兰。于是Peter和Brian决定前往那里寻找他的父亲，结果发现他是个酒鬼。他们决定玩一个喝酒游戏来证明他的亲子关系。与此同时，Stewie表现出不良行为，Lois打了他一顿。意识到自己喜欢被打屁股，Stewie竭尽所能惹麻烦。

当一个恶霸骚扰克里斯时，彼得为他辩护，但最终却揍了他。彼得意识到欺凌很有趣，开始欺负家里的每个人。最后，克里斯站出来对抗彼得，将他揍得头昏眼花。与此同时，Stewie没有涂防晒霜出去，变得痴迷于晒黑。在布莱恩将他留在日光浴室六个小时后，Stewie晒伤了，担心自己得了癌症。在等待癌症筛查结果期间，Stewie开始过着自己只剩下几天可活的生活，并用他的要求把布莱恩逼疯了。

Quagmire takes Peter to work but Peter messes things up, causing Quagmire to lose his job as a pilot. After not being able find another job, Peter and Cleveland make plans to help him get his old job back. When the plan fails, Quagmire receives advice from his idol, Hugh Hefner.

Peter helps Bill Clinton with his flat tire, and they soon become friends. They begin spending a lot of time together and Lois begins to believe that Bill inflicting bad influence on Peter. But when she confronts Bill, they end up having sex. Peter, upset that his wife would do this, tries to get back at Lois by having an affair of his own, but soon realizes that he loves her too much to do so. Meanwhile, Lois and Stewie try to potty-train Brian.

The Griffin family decides to start their own restaurant, though have a hard time attracting customers. After Joe promises to help, Peter is excited at the fact of it becoming a local hangout for the police. However, things don't really turn out as hoped, and instead it begins to be popular with the handicapped. When Peter attempts to change the place, a sudden twist of irony quickly changes his mind.

Lois gets a job as the church organist, so the family decides to begin going back to church. When Stewie gets sick after receiving communion, the congregation becomes convinced that he has been possessed by the devil. While on the run, the family ends up in Texas, where Peter begins to fit right in with the cowboys, Stewie enters the "Little Miss Texas" pageant, and Chris and Meg sneak into George W. Bush's house.

After Chris is expelled from school, he is sent to a boarding school that his grandfather Carter attended, but Chris doesn't exactly fit in. Meanwhile, the chicken returns to pick a fight with Peter.

Lois runs for mayor of Quahog, though she doesn't become the front-runner until she dumbs down her political views. Once in office, she becomes corrupted with the power that she now holds, and begins accepting bribes so that she can buy herself expensive things. Meanwhile, Peter comes to enjoy being the "first lady" of Quahog, and all of the perks that go along with it.

死神满足了Peter回到1984年时18岁的愿望，但只能持续一夜。他最终放弃了与Lois的约会，去和一位电影女演员一起玩。当他回到现在时，他很快意识到一切都不正常，因为他现在与那位前女演员结婚了，而Lois则和Quagmire在一起。与此同时，Stewie、Chris和Meg也都具有了Quagmire迷人的特质。